Multimodal Large Language Models for Medical Report Generation via Customized Prompt Tuning

Medical report generation from imaging data remains a challenging task in clinical practice. While large language models (LLMs) show great promise in addressing this challenge, their effective integration with medical imaging data still deserves in-depth exploration. In this paper, we present MRG-LLM, a novel multimodal large language model (MLLM) that combines a frozen LLM with a learnable visual encoder and introduces a dynamic prompt customization mechanism. Our key innovation lies in generating instance-specific prompts tailored to individual medical images through conditional affine transformations derived from visual features. We propose two implementations: prompt-wise and promptbook-wise customization, enabling precise and targeted report generation. Extensive experiments on IU X-ray and MIMIC-CXR datasets demonstrate that MRG-LLM achieves state-of-the-art performance in medical report generation. Our code will be made publicly available.

@article{li2025_2506.15477,
  title={ Multimodal Large Language Models for Medical Report Generation via Customized Prompt Tuning },
  author={ Chunlei Li and Jingyang Hou and Yilei Shi and Jingliang Hu and Xiao Xiang Zhu and Lichao Mou },
  journal={arXiv preprint arXiv:2506.15477},
  year={ 2025 }
}