Integrating Knowledge Graphs and Bayesian Networks: A Hybrid Approach for Explainable Disease Risk Prediction

Multimodal electronic health record (EHR) data is useful for disease risk prediction based on medical domain knowledge. However, general medical knowledge must be adapted to specific healthcare settings and patient populations to achieve practical clinical use. Additionally, risk prediction systems must handle uncertainty from incomplete data and non-deterministic health outcomes while remaining explainable. These challenges can be alleviated by the integration of knowledge graphs (KGs) and Bayesian networks (BNs). We present a novel approach for constructing BNs from ontology-based KGs and multimodal EHR data for explainable disease risk prediction. Through an application use case of atrial fibrillation and real-world EHR data, we demonstrate that the approach balances generalised medical knowledge with patient-specific context, effectively handles uncertainty, is highly explainable, and achieves good predictive performance.

@article{nzomo2025_2506.13920,
  title={ Integrating Knowledge Graphs and Bayesian Networks: A Hybrid Approach for Explainable Disease Risk Prediction },
  author={ Mbithe Nzomo and Deshendran Moodley },
  journal={arXiv preprint arXiv:2506.13920},
  year={ 2025 }
}