A Systematic Review of User-Centred Evaluation of Explainable AI in Healthcare

Despite promising developments in Explainable Artificial Intelligence, the practical value of XAI methods remains under-explored and insufficiently validated in real-world settings. Robust and context-aware evaluation is essential, not only to produce understandable explanations but also to ensure their trustworthiness and usability for intended users, but tends to be overlooked because of no clear guidelines on how to design an evaluation with users.This study addresses this gap with two main goals: (1) to develop a framework of well-defined, atomic properties that characterise the user experience of XAI in healthcare; and (2) to provide clear, context-sensitive guidelines for defining evaluation strategies based on system characteristics.We conducted a systematic review of 82 user studies, sourced from five databases, all situated within healthcare settings and focused on evaluating AI-generated explanations. The analysis was guided by a predefined coding scheme informed by an existing evaluation framework, complemented by inductive codes developed iteratively.The review yields three key contributions: (1) a synthesis of current evaluation practices, highlighting a growing focus on human-centred approaches in healthcare XAI; (2) insights into the interrelations among explanation properties; and (3) an updated framework and a set of actionable guidelines to support interdisciplinary teams in designing and implementing effective evaluation strategies for XAI systems tailored to specific application contexts.

@article{donoso-guzmán2025_2506.13904,
  title={ A Systematic Review of User-Centred Evaluation of Explainable AI in Healthcare },
  author={ Ivania Donoso-Guzmán and Kristýna Sirka Kacafírková and Maxwell Szymanski and An Jacobs and Denis Parra and Katrien Verbert },
  journal={arXiv preprint arXiv:2506.13904},
  year={ 2025 }
}