Improved Allergy Wheal Detection for the Skin Prick Automated Test Device

Background: The skin prick test (SPT) is the gold standard for diagnosing sensitization to inhalant allergies. The Skin Prick Automated Test (SPAT) device was designed for increased consistency in test results, and captures 32 images to be jointly used for allergy wheal detection and delineation, which leads to a diagnosis.Materials and Methods: Using SPAT data from $868$ patients with suspected inhalant allergies, we designed an automated method to detect and delineate wheals on these images. To this end, $10,416$ wheals were manually annotated by drawing detailed polygons along the edges. The unique data-modality of the SPAT device, with $32$ images taken under distinct lighting conditions, requires a custom-made approach. Our proposed method consists of two parts: a neural network component that segments the wheals on the pixel level, followed by an algorithmic and interpretable approach for detecting and delineating the wheals.Results: We evaluate the performance of our method on a hold-out validation set of $217$ patients. As a baseline we use a single conventionally lighted image per SPT as input to our method.Conclusion: Using the $32$ SPAT images under various lighting conditions offers a considerably higher accuracy than a single image in conventional, uniform light.

@article{daems2025_2506.05862,
  title={ Improved Allergy Wheal Detection for the Skin Prick Automated Test Device },
  author={ Rembert Daems and Sven Seys and Valérie Hox and Adam Chaker and Glynnis De Greve and Winde Lemmens and Anne-Lise Poirrier and Eline Beckers and Zuzana Diamant and Carmen Dierickx and Peter W. Hellings and Caroline Huart and Claudia Jerin and Mark Jorissen and Hanne Oscé and Karolien Roux and Mark Thompson and Sophie Tombu and Saartje Uyttebroek and Andrzej Zarowski and Senne Gorris and Laura Van Gerven and Dirk Loeckx and Thomas Demeester },
  journal={arXiv preprint arXiv:2506.05862},
  year={ 2025 }
}