Reasoning-Based Approach with Chain-of-Thought for Alzheimer's Detection Using Speech and Large Language Models

Societies worldwide are rapidly entering a super-aged era, making elderly health a pressing concern. The aging population is increasing the burden on national economies and households. Dementia cases are rising significantly with this demographic shift. Recent research using voice-based models and large language models (LLM) offers new possibilities for dementia diagnosis and treatment. Our Chain-of-Thought (CoT) reasoning method combines speech and language models. The process starts with automatic speech recognition to convert speech to text. We add a linear layer to an LLM for Alzheimer's disease (AD) and non-AD classification, using supervised fine-tuning (SFT) with CoT reasoning and cues. This approach showed an 16.7% relative performance improvement compared to methods without CoT prompt reasoning. To the best of our knowledge, our proposed method achieved state-of-the-art performance in CoT approaches.

@article{park2025_2506.01683,
  title={ Reasoning-Based Approach with Chain-of-Thought for Alzheimer's Detection Using Speech and Large Language Models },
  author={ Chanwoo Park and Anna Seo Gyeong Choi and Sunghye Cho and Chanwoo Kim },
  journal={arXiv preprint arXiv:2506.01683},
  year={ 2025 }
}