Ionic models, described by systems of stiff ordinary differential equations, are fundamental tools for simulating the complex dynamics of excitable cells in both Computational Neuroscience and Cardiology. Approximating these models using Artificial Neural Networks poses significant challenges due to their inherent stiffness, multiscale nonlinearities, and the wide range of dynamical behaviors they exhibit, including multiple equilibrium points, limit cycles, and intricate interactions. While in previous studies the dynamics of the transmembrane potential has been predicted in low dimensionality settings, in the present study we extend these results by investigating whether Fourier Neural Operators can effectively learn the evolution of all the state variables within these dynamical systems in higher dimensions. We demonstrate the effectiveness of this approach by accurately learning the dynamics of three well-established ionic models with increasing dimensionality: the two-variable FitzHugh-Nagumo model, the four-variable Hodgkin-Huxley model, and the forty-one-variable O'Hara-Rudy model. To ensure the selection of near-optimal configurations for the Fourier Neural Operator, we conducted automatic hyperparameter tuning under two scenarios: an unconstrained setting, where the number of trainable parameters is not limited, and a constrained case with a fixed number of trainable parameters. Both constrained and unconstrained architectures achieve comparable results in terms of accuracy across all the models considered. However, the unconstrained architecture required approximately half the number of training epochs to achieve similar error levels, as evidenced by the loss function values recorded during training. These results underline the capabilities of Fourier Neural Operators to accurately capture complex multiscale dynamics, even in high-dimensional dynamical systems.
View on arXiv@article{pellegrini2025_2505.14039,
title={ Learning High-dimensional Ionic Model Dynamics Using Fourier Neural Operators },
author={ Luca Pellegrini and Massimiliano Ghiotto and Edoardo Centofanti and Luca Franco Pavarino },
journal={arXiv preprint arXiv:2505.14039},
year={ 2025 }
}