CLIP-KOA: Enhancing Knee Osteoarthritis Diagnosis with Multi-Modal Learning and Symmetry-Aware Loss Functions

Knee osteoarthritis (KOA) is a universal chronic musculoskeletal disorders worldwide, making early diagnosis crucial. Currently, the Kellgren and Lawrence (KL) grading system is widely used to assess KOA severity. However, its high inter-observer variability and subjectivity hinder diagnostic consistency. To address these limitations, automated diagnostic techniques using deep learning have been actively explored in recent years. In this study, we propose a CLIP-based framework (CLIP-KOA) to enhance the consistency and reliability of KOA grade prediction. To achieve this, we introduce a learning approach that integrates image and text information and incorporate Symmetry Loss and Consistency Loss to ensure prediction consistency between the original and flipped images. CLIP-KOA achieves state-of-the-art accuracy of 71.86\% on KOA severity prediction task, and ablation studies show that CLIP-KOA has 2.36\% improvement in accuracy over the standard CLIP model due to our contribution. This study shows a novel direction for data-driven medical prediction not only to improve reliability of fine-grained diagnosis and but also to explore multimodal methods for medical image analysis. Our code is available atthis https URL.

@article{jeong2025_2504.19443,
  title={ CLIP-KOA: Enhancing Knee Osteoarthritis Diagnosis with Multi-Modal Learning and Symmetry-Aware Loss Functions },
  author={ Yejin Jeong and Donghun Lee },
  journal={arXiv preprint arXiv:2504.19443},
  year={ 2025 }
}