Alzheimer's disease (AD) leads to progressive cognitive decline, making early detection crucial for effective intervention. While deep learning models have shown high accuracy in AD diagnosis, their lack of interpretability limits clinical trust and adoption. This paper introduces a novel pre-model approach leveraging Jacobian Maps (JMs) within a multi-modal framework to enhance explainability and trustworthiness in AD detection. By capturing localized brain volume changes, JMs establish meaningful correlations between model predictions and well-known neuroanatomical biomarkers of AD. We validate JMs through experiments comparing a 3D CNN trained on JMs versus on traditional preprocessed data, which demonstrates superior accuracy. We also employ 3D Grad-CAM analysis to provide both visual and quantitative insights, further showcasing improved interpretability and diagnostic reliability.
View on arXiv@article{mustafa2025_2504.03230,
title={ Unlocking Neural Transparency: Jacobian Maps for Explainable AI in Alzheimer's Detection },
author={ Yasmine Mustafa and Mohamed Elmahallawy and Tie Luo },
journal={arXiv preprint arXiv:2504.03230},
year={ 2025 }
}