Radiology reports often remain incomprehensible to patients, undermining patient-centered care. We present ReXplain (Radiology eXplanation), an innovative AI-driven system that generates patient-friendly video reports for radiology findings. ReXplain uniquely integrates a large language model for text simplification, an image segmentation model for anatomical region identification, and an avatar generation tool, producing comprehensive explanations with plain language, highlighted imagery, and 3D organ renderings. Our proof-of-concept study with five board-certified radiologists indicates that ReXplain could accurately deliver radiological information and effectively simulate one-on-one consultations. This work demonstrates a new paradigm in AI-assisted medical communication, potentially improving patient engagement and satisfaction in radiology care, and opens new avenues for research in multimodal medical communication.
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