The lesion segmentation on endoscopic images is challenging due to its complex and ambiguous features. Fully-supervised deep learning segmentation methods can receive good performance based on entirely pixel-level labeled dataset but greatly increase experts' labeling burden. Semi-supervised and weakly supervised methods can ease labeling burden, but heavily strengthen the learning difficulty. To alleviate this difficulty, weakly semi-supervised segmentation adopts a new annotation protocol of adding a large number of point annotation samples into a few pixel-level annotation samples. However, existing methods only mine points' limited information while ignoring reliable prior surrounding the point annotations. In this paper, we propose a weakly semi-supervised method called Point-Neighborhood Learning (PNL) framework. To mine the prior of the pixels surrounding the annotated point, we transform a single-point annotation into a circular area named a point-neighborhood. We propose point-neighborhood supervision loss and pseudo-label scoring mechanism to enhance training supervision. Point-neighborhoods are also used to augment the data diversity. Our method greatly improves performance without changing the structure of segmentation network. Comprehensive experiments show the superiority of our method over the other existing methods, demonstrating its effectiveness in point-annotated medical images. The project code will be available on: https://github.com/ParryJay/PNL.
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