Decentralized finance (DeFi) has been the target of numerous profit-driven crimes, but the prevalence and cumulative impact of these crimes have not yet been assessed. This study provides a comprehensive assessment of profit-driven crimes targeting the DeFi sector. We collected data on 1141 crime events from 2017 to 2022. Of these, 1036 were related to DeFi (the main focus of this study) and 105 to centralized finance (CeFi). The findings show that the entire cryptoasset industry has suffered a minimum loss of US30B,withtwo−thirdsrelatedtoCeFiandone−thirdtoDeFi.FocusingonDeFi,ataxonomywasdevelopedtoclarifythesimilaritiesanddifferencesamongthesecrimes.AlleventsweremappedontotheDeFistacktoassesstheimpactedtechnicallayers,andthefinancialdamageswerequantifiedtogaugetheirscale.Theresultshighlightthatduringanattack,aDeFiactor(anentitydevelopingaDeFitechnology)canserveasadirecttarget(duetotechnicalvulnerabilitiesorexploitationofhumanrisks),asaperpetrator(throughmalicioususesofcontractsormarketmanipulations),orasanintermediary(bybeingimitatedthrough,forexample,phishingscams).ThefindingsalsoshowthatDeFiactorsarethefirstvictimsofcrimestargetingtheDeFiindustry:52