Existing deepfake detection methods fail to generalize well to unseen or degraded samples, which can be attributed to the over-fitting of low-level forgery patterns. Here we argue that high-level semantics are also indispensable recipes for generalizable forgery detection. Recently, large pre-trained Vision Transformers (ViTs) have shown promising generalization capability. In this paper, we propose the first parameter-efficient tuning approach for deepfake detection, namely DeepFake-Adapter, to effectively and efficiently adapt the generalizable high-level semantics from large pre-trained ViTs to aid deepfake detection. Given large pre-trained models but limited deepfake data, DeepFake-Adapter introduces lightweight yet dedicated dual-level adapter modules to a ViT while keeping the model backbone frozen. Specifically, to guide the adaptation process to be aware of both global and local forgery cues of deepfake data, 1) we not only insert Globally-aware Bottleneck Adapters in parallel to MLP layers of ViT, 2) but also actively cross-attend Locally-aware Spatial Adapters with features from ViT. Unlike existing deepfake detection methods merely focusing on low-level forgery patterns, the forgery detection process of our model can be regularized by generalizable high-level semantics from a pre-trained ViT and adapted by global and local low-level forgeries of deepfake data. Extensive experiments on several standard deepfake detection benchmarks validate the effectiveness of our approach. Notably, DeepFake-Adapter demonstrates a convincing advantage under cross-dataset and cross-manipulation settings. The source code is released at https://github.com/rshaojimmy/DeepFake-Adapter
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