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High-dimensional Inference and FDR Control for Simulated Markov Random Fields

11 February 2022
Haoyu Wei
Xiaoyu Lei
Yixin Han
Huiming Zhang
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Abstract

Identifying important features linked to a response variable is a fundamental task in various scientific domains. This article explores statistical inference for simulated Markov random fields in high-dimensional settings. We introduce a methodology based on Markov Chain Monte Carlo Maximum Likelihood Estimation (MCMC-MLE) with Elastic-net regularization. Under mild conditions on the MCMC method, our penalized MCMC-MLE method achieves ℓ1\ell_{1}ℓ1​-consistency. We propose a decorrelated score test, establishing both its asymptotic normality and that of a one-step estimator, along with the associated confidence interval. Furthermore, we construct two false discovery rate control procedures via the asymptotic behaviors for both p-values and e-values. Comprehensive numerical simulations confirm the theoretical validity of the proposed methods.

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