Deep learning models have gained remarkable performance on a variety of image classification tasks. However, many models suffer from limited performance in clinical or medical settings when data are imbalanced. To address this challenge, we propose a medical-knowledge-guided one-class classification approach that leverages domain-specific knowledge of classification tasks to boost the model's performance. The rationale behind our approach is that some existing prior medical knowledge can be incorporated into data-driven deep learning to facilitate model learning. We design a deep learning-based one-class classification pipeline for imbalanced image classification, and demonstrate in three use cases how we take advantage of medical knowledge of each specific classification task by generating additional middle classes to achieve higher classification performances. We evaluate our approach on three different clinical image classification tasks (a total of 8459 images) and show superior model performance when compared to six state-of-the-art methods. All codes of this work will be publicly available upon acceptance of the paper.
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