Purpose: Colorectal cancer (CRC) is the second most common cause of cancer mortality worldwide. Colonoscopy is a widely used technique for colon screening and polyp lesions diagnosis. Nevertheless, manual screening using colonoscopy suffers from a substantial miss rate of polyps and is an overwhelming burden for endoscopists. Computer-aided diagnosis (CAD) for polyp detection has the potential to reduce human error and human burden. However, current polyp detection methods based on object detection framework need many handcrafted pre-processing and post-processing operations or user guidance that require domain-specific knowledge. Methods: In this paper, we propose a convolution in transformer (COTR) network for end-to-end polyp detection. Motivated by the detection transformer (DETR), COTR is constituted by a CNN for feature extraction, transformer encoder layers interleaved with convolutional layers for feature encoding and recalibration, transformer decoder layers for object querying, and a feed-forward network for detection prediction. Considering the slow convergence of DETR, COTR embeds convolution layers into transformer encoder for feature reconstruction and convergence acceleration. Results: Experimental results on two public polyp datasets show that COTR achieved 91.49\% precision, 82.69% sensitivity, and 86.87% F1-score on the ETIS-LARIB, and 91.67% precision, 93.54% sensitivity, and 92.60% F1-score on the CVC-ColonDB. Conclusion: This study proposed an end to end detection method based on detection transformer for colorectal polyp detection. Experimental results on ETIS-LARIB and CVC-ColonDB dataset demonstrated that the proposed model achieved comparable performance against state-of-the-art methods.
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