Analyses of collider data, often assisted by modern Machine Learning methods, condense a number of observables into a few powerful discriminants for the separation of the targeted signal process from the contributing backgrounds. These discriminants are highly correlated with important physical observables; using them in the event selection thus leads to the distortion of physically relevant distributions. We present a novel method based on a differentiable estimate of mutual information, a measure of non-linear dependency between variables, to construct a discriminant that is statistically independent of a number of selected observables, and so manages to preserve their distributions in the event selection. Our strategy is evaluated in a realistic setting, the analysis of the Standard Model Higgs boson decaying into a pair of bottom quarks. Using the distribution of the invariant mass of the di-b-jet system to extract the Higgs boson signal strength, our method achieves state-of-the-art performance compared to other decorrelation techniques, while significantly improving the sensitivity of a similar, cut-based, analysis published by ATLAS.
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